Coding

Part:BBa_M36050

Designed by: Ryan Kent, Evan Clark   Group: Stanford BIOE44 - S11   (2011-05-02)

LexA gene

LexA is a repressor that represses SOS response genes coding for DNA polymerases required for repairing DNA damage. LexA binds to the SOS box region of the promoters of the SOS response genes until DNA damage is detected. DNA damage is detected by the SOS gene, recA. When recA binds to ssDNA is becomes activated and catalyzes the auto-proteolytic cleavage of lexA, allowing the other 40 some SOS response genes to be transcribed. LexA respresses itself so the detection of dmaged DNA also induces the transcription of lexA, therefore the system is self regulating.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None